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- New blood marker can identify Parkinsonian diseaseson September 18, 2023 at 11:59 pm
Is it possible that a single biomarker can detect all types of diseases related to dopamine deficiency in the brain? Yes, that's what a research group is discovering. 'We have observed that an enzyme in cerebrospinal fluid and in blood is a useful marker for identifying all types of Parkinson's-related diseases with high accuracy,' says the study leader.
- 'Circular logic' of RNAs in Parkinson's diseaseon September 18, 2023 at 2:51 pm
Researchers are gaining new insights into neurological diseases by studying circular RNAs (circRNAs) in brain cells. A new study has identified over 11,000 distinct RNA circles that characterized brain cells implicated in Parkinson's disease and Alzheimer's disease.
- Newly discovered trigger of Parkinson's upends common beliefson September 15, 2023 at 8:33 pm
A new study challenges a common belief in what triggers Parkinson's disease. Degeneration of dopaminergic neurons is widely accepted as the first event that leads to Parkinson's. But the new study suggests that a dysfunction in the neuron's synapses leads to deficits in dopamine and precedes the neurodegeneration. The findings open a new avenue for therapies in which drugs target neuron synapses before neurons degenerate.
- New insights into the development of Parkinson's disease in the brainon September 11, 2023 at 6:11 pm
Researchers have identified a new pathological mechanism for a familial type of Parkinson's disease caused by a mutation in the CHCHD2 gene. Mutant CHCHD2 protein is mislocalized in cells and leads to alpha-synuclein protein aggregates via interactions with another protein, known as Csnk1e/d. These findings indicate that Csnk1e/d inhibition may slow or halt Parkinson's disease development in patients with CHCHD2 mutations, providing new hope for affected families.
- Online AI-based test for Parkinson's disease severity shows promising resultson September 7, 2023 at 5:03 pm
A new artificial intelligence tool can help people with Parkinson's disease remotely assess the severity of their symptoms within minutes. While expert neurologists performed slightly better than the AI model, the AI model outperformed the primary care physicians with UPDRS certification.