A new study finds that neurons affected in Parkinson's disease can shut down without fully dying, allowing them to also switch off neighboring cells. The findings might give scientists a better understanding of how the condition wrecks havoc in the brain, as well as ideas for new treatments.
Researchers have discovered a new enzyme that inhibits the LRRK2 pathway. Mutations of the LRRK2 gene are the most common cause of genetic Parkinson's disease. The enzyme they found - called PPM1H - has been shown to possess remarkable properties to reverse the biology triggered by LRRK2.
Physical exams only provide a snapshot of a Parkinson's patient's daily tremor experience. Scientists have developed algorithms that, combined with wearable sensors, can continuously monitor patients at home or elsewhere to estimate the severity rating of their tremors based on the way that it manifests itself in movement patterns. This approach has the potential to provide clinicians with a full spectrum of their patients' tremors and medication response to effectively manage and treat this disorder.
Military veterans with post-traumatic stress disorder or concussion suffer from a thrashing form of sleep behavior at a rate that is far higher than the general population, according to a new study. Researchers next want to probe whether the sleep disorder might provide an early signal of the development of neurodegenerative conditions such as Parkinson's disease.